Tony Romo gets to see how the Dallas offense will look without NFL rushing champion DeMarco Murray.
So do the New York Giants in an opener between NFC East rivals.
Joseph Randle was Murray's backup for two seasons. Darren McFadden was a disappointment in Oakland as the No. 4 overall pick in 2008.
Those are the two running backs likely to see the most work against the Giants on Sunday night since Christine Michael probably won't be ready just a week after coming over in a trade from Seattle.
Murray broke all-time NFL rushing leader Emmitt Smith's franchise record with 1,845 yards last season, easing the load on Romo as the Cowboys won the division. Dallas beat Detroit in a wild-card game before losing to Green Bay in the divisional round of the playoffs.
The preseason did little to settle how Dallas will fill the void, but that didn't seem to bother coach Jason Garrett. He's not even interested in sharing who will be lined up behind Romo for Dallas' first offensive snap.
The Giants have a big hole to fill, too, and don't know for how long. After rejoining his team a week before the opener, star pass rusher Jason Pierre-Paul returned home to South Florida to continue his recovery from a fireworks accident that damaged his right hand.
If the Giants have to outscore the Cowboys, Eli Manning is visiting a stadium where he's done that before. Going into his 11th straight opener, Manning has averaged 321 yards passing and more than three touchdowns in six games at the $1.2 billion home of the Cowboys.
That included the first regular-season game there in 2009, a 33-31 New York win that he commemorated by writing on a wall in the locker room.
Things to consider going into the 18th meeting between Romo and Manning, including the day Romo became the Dallas starter when replaced Drew Bledsoe at halftime of a 36-22 New York win in 2006.