Eli Manning won his first four starts at AT&T Stadium, including the first regular-season game in the building in 2009, before losing in 2013. But the Giants come in without their two top offensive options sidelined with knee injuries: WR Victor Cruz, out for the season, and RB Rashad Jennings.
New York must find a way to shut down DeMarco Murray, who could break Jim Brown's mark of six 100-yard rushing games to start a season. Murray leads the NFL with 785 yards rushing and six touchdowns.
"There's no emergence, he's been a heck of a football player for all of the years that I've been around watching him," Giants coach Tom Coughlin said.