Drew Stanton will make his second start at quarterback since Carson Palmer went down with a season-ending knee injury. He threw for a career-high 306 yards last week against Detroit and completed passes to 10 different receivers. But he also threw two interceptions and will be challenged by Seattle's unfriendly confines and its stellar secondary.
"You look at everything that's transpired and we dealt with a lot of stuff, but we've been successful," Stanton said. "We can't start listening to outside critics because early on in the year, people tried to write us off when Carson was out and we had a lot of question marks — people wanted to sit here and doubt us. So we've done a good job of blocking that out."
Here's what else to watch as Arizona and Seattle meet for the first of two games in less than a month:
Seattle running back Marshawn Lynch is coming off his two best games of the season and his first time topping 100 yards in consecutive games since Weeks 9 and 10 of last season. He's also heading into Sunday $100,000 lighter in the wallet after getting fined by the league for violations of its media policy. Lynch rushed for 140 yards against the Giants and followed up with 124 against Kansas City.
If he can reach the century mark against Arizona he would break the Cardinals' streak of 20 straight games without allowing a 100-yard rusher and post three-straight 100-yard games for the first time since the end of the 2012 season.
Seattle knows it's about to face an assortment of blitzes from Arizona's defense. The Cardinals have 10 sacks in their past two games. Alex Okafor has three of his team-high five sacks this season in the past two games.
In four games against Russell Wilson, Arizona has 11 sacks.
Seattle's run defense surrendered 159 yards to Jamaal Charles last week, the most by any running back against Seattle since Adrian Peterson in 2012. The Seahawks can't let Andre Ellington have the same success if they want to put pressure on Stanton.
In the past three games, Arizona is allowing nearly nothing in the second half. Opponents have had 18 second-half possessions during those three games and Arizona has allowed only seven points and forced six turnovers.
If facing the team with the best record in the NFL wasn't difficult enough, the Seahawks don't get much recovery time. They'll have just three days of rest after Sunday's game before a Thanksgiving night showdown with rival San Francisco.
"We never worry about a short week there's nothing we can do about it," Seattle coach Pete Carroll said.