The Kansas City Chiefs will be without two of their leading rushers when they face the New England Patriots in a rematch of last season’s AFC championship game.
Damien Williams is inactive with a rib injury and Darrel Williams was placed on injured reserve Thursday with a hamstring injury.
That leaves rushing duties to LeSean McCoy, Darwin Thompson or Spencer Ware, who signed earlier in the week.
The Chiefs can clinch the AFC West title with a win and Oakland loss to Tennessee.
The Patriots, who can extend their NFL record to 11 consecutive playoff berths with a win, will also be missing a key offensive cog. Center Ted Karras is out with a knee injury. James Ferentz is expected to start in his place.
Pittsburgh running back James Conner (shoulder) is out once again for his team’s game against the Arizona Cardinals.
Conner hasn’t played much since running for 145 yards against the Miami Dolphins on Oct. 28. He tried to return on Nov. 14 against the Browns, running for 10 yards on five carries, but hasn’t played since.
The Steelers are trying to win for the seventh time in eight games. Quarterback Devlin Hodges, who came to the team as a rookie free agent, will be making his third start.
Oakland Raiders running back Josh Jacobs is inactive against Tennessee with a shoulder injury.
Jacobs ranks fifth in the NFL with 1,061 yards rushing but has been playing through an injured shoulder since hurting it Oct. 20 at Green Bay. The Raiders are also without right tackle Trent Brown, who has a pectoral injury.
Cornerback Tramaine Brock will make his debut for Tennessee after being claimed off waivers earlier in the week. Brock is playing in a thin secondary that is missing starter Adoree Jackson (foot) and backup LeShaun Sims (ankle) this week and has already placed starter Malcolm Butler on injured reserve.
Jaguars safety Ronnie Harrison will miss his second consecutive game because of a concussion. Undrafted rookie Andrew Wingard will make start in his place again.
The Chargers ruled out linebacker Denzel Perryman and safety Roderic Teamer on Saturday, saying neither is injury related.
KANSAS CITY-NEW ENGLAND
Chiefs: RB Damien Williams, CB Rashad Fenton, CB Morris Claiborne, OL Jackson Barton, OL Nick Allegretti, TE Deon Yelder, QB Chad Henne.
Patriots: C Ted Karras, DL Byron Cowart, CB Joejuan Williams, QB Cody Kessler, OL Korey Cunningham, TE Ryan Izzo, RB Damien Harris.
Steelers: QB Paxton Lynch, WR JuJu Smith-Schuster, CB Artie Burns, RB James Conner, LB Tuzar Skipper, OL Chukwuma Okorafor, TE Zach Gentrys.
Cardinals: WR KeeSean Johnson, CB Jalen Davis, S Deionte Thompson, LB Kylie Fitts, OL Lamont Gaillard, OL Josh Miles, TE Dan Arnold.
Chargers: QB Easton Stick, S Roderic Teamer, CB Tevaughn Campbell, LB Denzel Perryman, G Spencer Drango, OT Trey Pipkins, DT Jerry Tillery.
Jaguars: QB Joshua Dobbs, CB Tae Hayes, S Ronnie Harrison, OL Brandon Thomas, DT Carl Davis, TE Seth DeValve, DT Dontavius Russell.
Titans: CB Adoree Jackson, CB LeShaun Sims, WR Adam Humphries, LB Darren Bates, O Kevin Pamphile, DL Matt Dickerson, LB Derick Roberson.
Raiders: RB Josh Jacobs, T Trent Brown, WR Hunter Renfrow, LB Kyle Wilber, QB Mike Glennon, CB Isaiah Johnson, DT Terrell McClain.
Ravens: QB Trace McSorley, WR Jaleel Scott, CB Anthony Averett, CB Iman Marshall, C Hroniss Grasu, DT Justin Ellis, OG Ben Powers.
Bills: RB T.J. Yeldon, S Dean Marlowe, OG Ike Boettger, RT Ty Nsekhe, WR Duke Williams, TE Tommy Sweeney, DT Vincent Taylor.
Bengals: QB Jake Dolegala, WR A.J. Green, CB Torry McTyer, G/OT John Jerry, TE Mason Schreck, DE Sam Hubbard.
Browns: WR Taywan Taylor, S Eric Murray, Olivier Vernon, RT Chris Hubbard, TE Pharaoh Brown, TE Demetrius Harris, DT Justin Zimmer.
MIAMI-NEW YORK JETS
Dolphins: CB Linden Stephens, G Shaq Calhoun, C/G Evan Brown, WR Trevor Davis, DT Zach Sieler, DE Taco Charlton, LB Trent Harris.
Jets: S Jamal Adams, RB Le'Veon Bell, CB Brian Poole, CB Arthur Maulet, S Matthias Farley, OL Chuma Edoga, LB Paul Worrilow.
Broncos: WR Juwann Winfree, CB Shakial Taylor, C Patrick Morris, OLB Malik Reed, G Ron Leary, T Calvin Anderson, DL Jonathan Harris.
Texans: WR Steven Mitchell, WR Will Fuller, S Mike Adams, CB Cornell Armstrong, RB Taiwan Jones, DE Carlos Watkins, NT Eddie Vanderdoes.
SAN FRANCISCO-NEW ORLEANS
49ers: WR Marquise Goodwin, WR Dante Pettis, S Jaquiski Tartt, RB Jeff Wilson Jr., DL Jullian Taylor, TE Levine Toilolo.
Saints: CB Patrick Robinson, DB Saquan Hampton, FB Zach Line, LB A.J. Klein, LB Kiko Alonso, OL Will Clapp, OL Andrus Peat.
Colts: WR T.Y. Hilton, CB Kenny Moore II, K Adam Vinatieri, QB Chad Kelly, LB E.J. Speed, G/T Le’Raven Clark, DT Trevon Coley.
Buccaneers: G Alex Cappa, RB T.J. Logan, OLB Anthony Nelson, WR Scotty Miller, OLB Kazin Daniels, T Jerald Hawkins, TE Jordan Leggett.
Lions: QB Matthew Stafford, CB Michael Jackson, CB Jamal Agnew, G/C Beau Benzschawel, G Oday Aboushi, DE Da’Shawn Hand, DE Austin Bryant.
Vikings: WR Adam Thielen, DT Hercules Mata’afa, LB Cameron Smith, G Dru Samia, T Oli Udoh, T Aviante Collins, DT Jalyn Holmes.
Redskins: WR Paul Richardson Jr., QB Colt McCoy, WR Trey Quinn, LB Josh Harvey-Clemons, CB Aaron Colvin, LB Chris Odom, C Ross Pierschbacher.
Packers: WR Ryan Grant, CB Kevin King, RB Dexter Williams, CB Tony Brown, CB Ka'dar Hollman, G/T Adam Pankey, T Yosh Nijman.
Panthers: DB Corn Elder, DL Christian Miller, OL Chris Reed, OL Greg Little, DL Woodrow Hamilton, TE Greg Olsen, DL Stacy McGee.
Falcons: WR Brandon Powell, S Sharrod Neasman, DE Jhn Cominsky, OG Jamon Brown, OT Ty Sambrailo, OG James Carpenter, DT Deadrin Senat.
More AP NFL: https://apnews.com/NFL and https://twitter.com/AP_NFL