Colts will be missing top 2 running backs against Jaguars

Indianapolis Colts running back Nyheim Hines (21) runs against Kansas City Chiefs cornerback L'Jarius Sneed (38) during the first half of an NFL football game, Sunday, Sept. 25, 2022, in Indianapolis. (AP Photo/AJ Mast)

Indianapolis Colts linebacker Shaquille Leonard is helped off the field after an injury in the first half of an NFL football game against the Tennessee Titans in Indianapolis, Fla., Sunday, Oct. 2, 2022. (AP Photo/Darron Cummings)

Indianapolis Colts running back Jonathan Taylor is tackled by Kansas City Chiefs linebacker Nick Bolton (32) on a fourth down during the second half of an NFL football game, Sunday, Sept. 25, 2022, in Indianapolis. Taylor was stopped short of the first down. (AP Photo/Michael Conroy)

Indianapolis Colts running back Nyheim Hines (21) stumbles as he tries to get up after being injured against the Denver Broncos during the first half of an NFL football game, Thursday, Oct. 6, 2022, in Denver. (AP Photo/David Zalubowski)

Jacksonville Jaguars wide receiver Marvin Jones Jr. (11) catches the ball between Houston Texans cornerback Derek Stingley Jr. (24) and linebacker Jalen Reeves-Maybin (44) during the second half of an NFL football game in Jacksonville, Fla., Sunday, Oct. 9, 2022. (AP Photo/Phelan M. Ebenhack)