Patrick Mahomes' 3 TDs lead Chiefs past 49ers 44-23

Kansas City Chiefs wide receiver Marquez Valdes-Scantling, left, catches a pass in front of San Francisco 49ers cornerback Charvarius Ward (7) during the second half of an NFL football game in Santa Clara, Calif., Sunday, Oct. 23, 2022. (AP Photo/Godofredo A. Vásquez)

San Francisco 49ers head coach Kyle Shanahan watches from the sideline during the first half of his team's NFL football game against the Kansas City Chiefs in Santa Clara, Calif., Sunday, Oct. 23, 2022. (AP Photo/Jed Jacobsohn)

Kansas City Chiefs wide receiver Mecole Hardman (17) celebrates after scoring a touchdown against the San Francisco 49ers during the second half of an NFL football game in Santa Clara, Calif., Sunday, Oct. 23, 2022. (AP Photo/Godofredo A. Vásquez)

Kansas City Chiefs wide receiver Justin Watson (84) celebrates after catching a touchdown pass during the second half of an NFL football game against the San Francisco 49ers in Santa Clara, Calif., Sunday, Oct. 23, 2022. (AP Photo/Jed Jacobsohn)

Kansas City Chiefs quarterback Patrick Mahomes (15) passes against the San Francisco 49ers during the first half of an NFL football game in Santa Clara, Calif., Sunday, Oct. 23, 2022. (AP Photo/Jed Jacobsohn)

San Francisco 49ers running back Christian McCaffrey (23) runs in front of Kansas City Chiefs defensive end Frank Clark (55) during the first half of an NFL football game in Santa Clara, Calif., Sunday, Oct. 23, 2022. (AP Photo/Godofredo A. Vásquez)

Kansas City Chiefs running back Clyde Edwards-Helaire, left, runs past San Francisco 49ers safety Talanoa Hufanga (29) and linebacker Dre Greenlaw (57) to score on a rushing touchdown during the second half of an NFL football game in Santa Clara, Calif., Sunday, Oct. 23, 2022. (AP Photo/Jed Jacobsohn)

Kansas City Chiefs defensive tackle Chris Jones (95) celebrates defensive end Frank Clark during the second half of an NFL football game against the San Francisco 49ers in Santa Clara, Calif., Sunday, Oct. 23, 2022. (AP Photo/Godofredo A. Vásquez)