INDIANAPOLIS (6-4) at HOUSTON (6-4)

Thursday, 8:20 p.m. ET, FOX, NFL Network, Amazon Prime Video

OPENING LINE — Texans by 3½

RECORD VS. SPREAD — Indianapolis 5-4-1, Houston 5-5

SERIES RECORD — Colts lead 27-8.

LAST MEETING — Colts beat Texans 30-23, Oct. 20

LAST WEEK — Colts beat Jaguars 33-13; Texans lost to Ravens 41-7

AP PRO32 RANKING — Colts and Texans tied at No. 11

COLTS OFFENSE — OVERALL (21), RUSH (4), PASS (28).

COLTS DEFENSE — OVERALL (11), RUSH (9), PASS (11).

TEXANS OFFENSE — OVERALL (7), RUSH (5), PASS (14).

TEXANS DEFENSE — OVERALL (25), RUSH (13), PASS (29).

STREAKS, STATS AND NOTES — Colts have won three straight and five of past six in series, including three consecutive road games. ... Indy has won first three games against AFC South foes this season, including 30-23 victory over Texans in October. ... Colts have limited past six opponents to 17.3 points, 73.0 yards and have not allowed 100-yard rusher in 28 consecutive games. ... Indy ran for 264 yards in Sunday's win over Jacksonville but will be without starting RB Marlon Mack (fractured right hand). Jordan Wilkins and Jonathan Williams are expected to split bulk of carries with Mack out. ... WR T.Y. Hilton has missed past three games with quad injury and is expected to be game-time decision. ... DE Justin Houston has sack in six straight games for third time in career, longest active streak in NFL. ... K Adam Vinatieri needs three field goals to become first player in NFL history with 600. ... Houston tied for second in NFL with 13 forced fumbles. ... QB Deshaun Watson has 16 touchdown passes with just two interceptions and three rushing touchdowns in six games in prime time. Has thrown three TD passes in two straight home games. ... RB Duke Johnson one of two RBs to have at least 250 catches (259) and 10 or more touchdown receptions (10) since 2015. ... WR DeAndre Hopkins had seven receptions last week to become second-youngest player to reach 600 in NFL history. Had nine catches for 106 yards and TD in previous game against Colts. ... WR Kenny Stills had season-high 105 yards receiving in first game against Colts this season. ... Darren Fells tied for first in NFL among tight ends with six TD catches. ... LB Zach Cunningham led team with 10 tackles last week. ... LB Brennan Scarlett had seven tackles and sack last week. ... S Justin Reid has had eight tackles or more in two of past three home games. ... Fantasy tip: Hilton could be good pickup this week after piling up 82 receptions for 1,519 yards and 10 TDs in 15 games vs. Texans.

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