Injuries have sunk the Rams, whose four games were outside the league's toughest division. Now they dive into the NFC West for four of their next five, including two with the Niners.
San Francisco has won six in row on Monday nights, outscoring opponents 164-49. QB Colin Kaepernick is 3-0 on Monday nights with six TDs, no interceptions.
Although the Niners have, by far, the better Super Bowl history, St. Louis will be remembering its past in prime time: The Rams will don throwback uniforms worn by their 1999 Super Bowl championship team, the Greatest Show on Turf.