While much of Aldon Smith's focus will be on trying to bring down Denver quarterback Peyton Manning, Oakland's pass rusher also will be in a little competition with the Broncos' edge rushers.
With Smith and teammate Khalil Mack on one side and Denver's DeMarcus Ware and Von Miller on the other, the game Sunday between the Raiders (2-2) and Broncos (4-0) will feature some of the best pass rushers around.
Denver's group has been tops so far this season with an NFL-best 18 sacks through four games that has the Broncos on pace to tie the single-season sacks record of 72 set by Chicago in 1984.
Denver's revamped defense under new coordinator Wade Phillips, who replaced current Raiders coach Jack Del Rio, has gotten sacks from 11 players, led by Ware's 4 1/2.
Derek Carr has made major strides in dealing with pressure in his second season as Raiders quarterback, but he will have to be at the top of his game against this defense.
Oakland's pass rushers haven't been nearly as prolific with just eight sacks. But Smith is finding his groove after signing two days before the season opener, and the Broncos have struggled to protect Manning, allowing 10 sacks.
The line will need to do a better job against Smith and Mack.
"Everybody has to account for them," Manning said. "Obviously, receivers have to get open on time. Obviously, offensive line has to be on top of all communications. You have to just account for those guys because both of them can create turnovers and cause long down-and-distances."